Modulation of Diseased Neutrophils Using Targeted Payload Delivery
We generated a targeted neutrophil nanoparticle platform (TENNs) that preferentially doses the activated neutrophil population in chronic disease
When administered in-vivo, the targeted nanoparticles specifically modulate neutrophils but do not ablate them, avoiding neutropenia
The technology is a platform for numerous diseases
Neutrophils are a large and highly mobile cell population with rapid turnover
TENNs specifically target neutrophils throughout the body and have long bioavalability
Requires modulation and not ablation which leads to neutropenia
TENNs use drugs targeting specific disease mechanisms that do not ablate neutrophils
Requires a non-toxic neutrophil modulating agents
TENNs deliver concentrated drug to the neutrophils preventing toxicity